A major new priority is
being promoted at the National Institutes of Health
(NIH)translational research. The idea is to devote more
resources to the challenge of translating basic research into
tools and interventions that can be used to diagnose, treat and
prevent disease. The goal is to bridge the gap between bench
and bedside, and to facilitate the flow of scientific discovery
to practical application. It is an important priority for NIH
and entirely fitting with its mission.
New programs and funding announcements
signal the NIH priority, and in some cases entire institutes
have been reorganized in response. The National Institute of
Mental Health (NIMH) appears to be leading the way, with two
entire divisions now devoted to translational research and
treatment development.
Writing last year in the Journal of the
American Medical Association (JAMA), NIH Director Elias
Zerhouni, MD, explained that leaders in basic science
are concerned at the increasing difficulty of finding talented,
high-quality scientific collaborators who understand human
disease and can both translate and clinically apply insights
from basic science (Vol. 294, No. 11, page 1,356).
Zerhouni hopes to address this concern by transforming
translational and clinical science into an entire discipline.
It is interesting to look more closely at
the kinds of basic science that Zerhouni cites as facing a
trans-lational hurdle: He mentioned genomics, proteomics,
metabolomics and high-sensitivity biochemical methods in the
2005 JAMA article. The view from NIH is that
multidisciplinary teams are needed to achieve the translation in such areas, and that higher value needs
to be placed on translational science itself.
The translational challenge
In the case of NIMH, the new emphasis on
translational research is the cause of some concern. Many
psychologistsespecially social
psychologistsperceive that resources are being directed
away from their kind of basic research so that
translational research can grow. The psychologists are
struggling to find a place for themselves in this new world of
priorities, and they are resisting the suggestion that they
need to somehow change their approach (if they want funding).
Until recently, I shared the concern of my
colleagues. I worried that the new emphasis on translational
research would mean diminished resources for basic
psychological research. Yet, I also understood the challenge of
translating advances in genomics or proteomics into something
that could actually find use in treatment and intervention. I dont envy the
scientists who work in those fields because the translational
challenge is huge.
And then it dawned on me: Psychology has
no problem with translation. Indeed, psychology is all
about translation; it has been from the beginning. Translation
is woven into the fabric of our discipline, and we excel at it.
Other fields of science are challenged by translation
because translation is not a part of their culture. It defines
psychology.
A model of translation
Consider the model programs identified by
the Substance Abuse and Mental Health Services Administration
(SAMHSA) for preventing or reducing substance abuse and for
treating a variety of mental health disturbances. SAMHSA
identifies a program as a model program only when
substantial evidence has accumulated to show that it works.
The intervention that shows up over and
over again among the SAMHSA model programs is
cognitive-behavioral therapy. This is an intervention
strategy with roots in basic psychological research. It
owes its successful translation to
psychologistsresearch psychologists, clinical
psychologists and psychology practitioners who have worked
together as a community over a long period of time to
establish basic understanding and to develop effec-tive
interventions.
Translation in psychology extends far
beyond health-related areas. Research on human factors,
education, organizational behavior, decision-making,
environmental design and social influence has led to
interventions and innovations that allow people to live
healthier, safer and more productive lives. It is all about the
translation of basic research into practical application.
Psychology is a model discipline for translational research in
health-related areas and beyond. Rather than being threatened
by the new emphasis at NIH, psychology should be flattered.
It is recognition that other fields of science need to follow
the good example of psychology by placing higher
priority on the translation of their basic science into
practical and useable interventions and applications.
NIH may not even realize the good thing it
has in psychologyone of the few scientific disciplines
to have already met the new challenge of translation. If NIH
wants to succeed in this endeavor, it should look to psychology
to help lead the way.