Origins and Development of Schizophrenia: Advances in Experimental Psychopathology

Pages: 557
Item #: 4318730
ISBN: 978-1-55798-497-5
List Price: $34.95
Member/Affiliate Price: $29.95
Copyright: 1998
Format: Hardcover
Note: This book is out of print and no longer available for purchase.

The causes and fundamental nature of schizophrenia have challenged researchers for decades. But recently, technological advances and new findings in psychological science, genetics, neurobiology, and related fields have greatly quickened the pace of this research. Origins and Development of Schizophrenia presents some of the most exciting experimental psychopathology research in this area during the past 10 years and sheds new light on this complex and devastating mental disorder.

This volume presents an exhaustive range of empirically based models and viewpoints on the pathogenesis of schizophrenia, addressing models of liability and etiology, neurocognitive processes, approaches to vulnerability, and developmental processes. Chapter authors fully acknowledge this disorder's complexity by exploring the genetic, neurobiological, neurophysiological, cognitive, emotional, and behavioral influences, all within an experimental psychopathology perspective.

Table of Contents

List of Contributors

Prologue: The Origins and Development of Schizophrenia
—Mark F. Lenzenweger and Robert H. Dworkin

I. Models of Liability and Etiology

  1. Genotypes, Genes, Genesis, and Pathogenesis in Schizophrenia
    —Irving I. Gottesman and Steven O. Moldin
  2. A Two-Hit Working Model of the Etiology of Schizophrenia
    —Sarnoff A. Mednick, Jennifer B. Watson, Matti Huttunen, Tyrone D. Cannon, Heikki Katila, Ricardo Machon, Birgitte Mednick, Meggin Hollister, Josef Parnas, Fini Schulsinger, Nina Sajaniemi, Peter Voldsgaard, Reijo Pyhala, Dan Gutkind, and Xueyi Wang
  3. Genetic and Perinatal Influences in the Etiology of Schizophrenia: A Neurodevelopmental Model
    —Tyrone D. Cannon
  4. Schizotypy and Schizotypic Psychopathology: Mapping an Alternative Expression of Schizophrenia Liability
    —Mark F. Lenzenweger
  5. Regulation of Information Flow in the Nucleus Accumbens: A Model for the Pathophysiology of Schizophrenia
    —Anthony A. Grace and Holly Moore

II. Neurocognitive Processes

  1. How Are Deficits in Motion Perception Related to Eye-Tracking Dysfunction in Schizophrenia?
    —Philip S. Holzman, Yue Chen, Ken Nakayama, Deborah L. Levy, and Steven Matthysse
  2. Disinhibition in Antisaccade Performance in Schizophrenia
    —Deborah L. Levy, Nancy R. Mendell, Christian A. LaVancher, Joanna Brownstein, Olga Krastoshevsky, Laurie Teraspulsky, Kimberly S. McManus, Yungtai Lo, Rebecca Bloom, Steven Matthysse, and Philip S. Holzman
  3. Lateralization, Memory, and Language in Schizophrenia: Some Facts and an Artifact
    —Brendan A. Maher and Theo C. Manschreck
  4. Neural Mechanisms Underlying Hallucinations in Schizophrenia: The Role of Abnormal Fronto-Temporal Interactions
    —Emily Stern and David A. Silbersweig
  5. The Role of Cognitive Psychology in Guiding Research on Cognitive Deficits in Schizophrenia: A Process-Oriented Approach
    —Raymond A. Knight and Steven M. Silverstein

III. Approaches to Vulnerability

  1. Neurocognitive Vulnerability Factors for Schizophrenia: Convergence Across Genetic Risk Studies and Longitudinal Trait–State Studies
    —Keith H. Nuechterlein, Robert F. Asarnow, Kenneth L. Subotnik, David L. Fogelson, Joseph Ventura, Richard D. Torquato, and Michael E. Dawson
  2. Backward-Masking Performance in Schizophrenia
    —Michael F. Green and Keith H. Nuechterlein
  3. High-Risk Research in Schizophrenia: New Strategies, New Designs
    —Barbara A. Cornblatt, Michael Obuchowski, Alyson Andreasen, and Christopher Smith
  4. Affective Expression and Affective Experience in Schizophrenia
    —Robert H. Dworkin, Harriet Oster, Scott C. Clark, and Stephanie R. White

IV. Developmental Processes, Course, and Outcome

  1. Prediction From Longitudinal Assessments of High-Risk Children
    —L. Erlenmeyer-Kimling, Simone A. Roberts, Donald Rock, Ulla Hildoff Adamo, Barbara Maminski Shapiro, and Sky Pape
  2. Expressed Emotion and the Pathogenesis of Relapse in Schizophrenia
    —Jill M. Hooley and Jordan B. Hiller
  3. Developmental Changes in the Behavioral Expression of Vulnerability for Schizophrenia
    —Elaine F. Walker, Kym M. Baum, and Donald Diforio

Epilogue: Comments on the Origins and Development of Schizophrenia
—Richard R. J. Lewine

Author Index

Subject Index

About the Editors