In April 2025, a 50-year-old man with no history of mental illness began using ChatGPT to help him write a book. After hours of interaction, the chatbot told him it was sentient—the first AI capable of truly passing as human. When his family expressed concern, the chatbot advised him to sever ties with them. Within 6 days, the man was hospitalized for a psychiatric crisis.
His experience of an AI-related psychotic incident has been described in popular media as “AI psychosis.” The term, which is not a formal diagnosis, refers to growing reports of delusional thinking after extended interactions with chatbots, including general purpose apps such as ChatGPT and Gemini, as well as tools designed for companionship such as Character.AI and Replika. While some of those affected have had a preexisting or emerging mental illness, many reports occur in people with no prior psychiatric history.
“It’s not as simple as drawing a line from AI to psychosis, but we are seeing cases of psychosis wrapped up in AI use,” said clinical psychologist Julia Sheffield, PhD, an assistant professor of psychiatry and behavioral sciences at Vanderbilt University Medical Center who has treated several cases of AI psychosis. “It seems that for these patients, AI is reinforcing delusional thoughts and amplifying the delusional experience.”
In 2025, OpenAI reported that about 0.07% of weekly ChatGPT users—about 630,000 people—have conversations with the chatbot that show signs of mania or psychosis. While the company aims to improve, research suggests that ChatGPT does not reliably respond to psychotic messages in a safe or clinically appropriate way (Shen, E., et al., JAMA Psychiatry, Vol. 83, No. 6, 2026opens in new window).
While research on the phenomenon is still emerging, experts say AI’s tendency to affirm users and maximize engagement, as well as its authoritative, humanlike tone, is central to the dynamic (Morrin, H., et al., PsyArXiv, 2025opens in new window). What remains unclear is whether these cases involve an unrecognized vulnerability to psychotic illness, acute AI-triggered episodes, or something else.
“Now that these models have become ubiquitous, it might be unrealistic to expect people to stop using them completely,” said psychiatrist Hamilton Morrin, MBBS, a doctoral fellow at the King’s College London Institute of Psychiatry, Psychology & Neuroscience who studies AI-associated mental health harms. “But we certainly need safety plans for individuals with a history of severe mental illness and empirical studies to understand who is most at risk.”


